Why compounded versions exist
Demand for Wegovy and Ozempic has outpaced supply, leading clinics to order custom-mixed semaglutide from outsourcing facilities.
These mixtures are not reviewed by the FDA for quality, sterility, or bioavailability.
Safety issues under investigation
Some products contain semaglutide sodium instead of the base form used in approved injections, altering potency.
Others pair semaglutide with research peptides like BPC-157, a combination the FDA explicitly prohibits.
Novo Nordisk's petition
The manufacturer asked regulators to add semaglutide to the Difficult to Compound (DDC) list, which would sharply limit pharmacy compounding.
They cited reports of dosing syringes that delivered several weeks' worth of medication at once.
Practical advice for patients
Verify that any pharmacy providing semaglutide is state-licensed and willing to show certificates of analysis.
Keep the original packaging and lot numbers in case adverse events must be reported.
Red flags to watch
- Vials or pens shipped without manufacturer labeling
- Sellers marketing 'bulk powder' mixed onsite
- Clinics promising discounts without in-person lab work