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UCLA Explains 'Ozempic Face' and Other GLP-1 Side Effects

Latest GLP-1 legal updates and medical findings.

• UCLA Health News

UCLA Explains 'Ozempic Face' and Other GLP-1 Side Effects

Dermatologists and endocrinologists describe cosmetic changes alongside serious gastrointestinal warnings.

15-20%
Average weight loss cited
4
Weeks many notice facial hollowing
2x
Higher dehydration complaints

What is 'Ozempic face'?

UCLA dermatologists note that sudden fat loss in the cheeks and temples can make patients look gaunt or older.

Collagen also declines when weight is lost too quickly, leaving skin less elastic and more prone to sagging.

Medical context behind the look

GLP-1 drugs slow gastric emptying, which can trigger malnutrition if patients cannot tolerate enough calories.

Clinicians are monitoring vitamin and protein deficits that further weaken skin and connective tissue.

Other side effects flagged by UCLA

Beyond appearance, physicians warn about gallbladder inflammation, pancreatitis, severe constipation, and mood changes.

Patients with existing eye disease are urged to report any sudden vision changes immediately.

Practical guidance for patients

Schedule regular check-ins so providers can adjust dosing or pause therapy when side effects escalate.

Discuss informed consent forms that clearly cover nutritional, cosmetic, and gastrointestinal risks.

Steps UCLA recommends

  • Hydrate aggressively and include electrolyte replacements
  • Work with a dietitian to maintain muscle mass
  • Document any cosmetic or neurological symptoms for your medical file

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